Wolfram Computation Meets Knowledge

Wolfram Summer School


Enrique Barrajón

Summer School

Class of 2013


Enrique Barrajón has a Spanish and European certificate in Medical Oncology. He holds a PhD in Medicine from the Universidad de Navarra and a master’s degree in Statistics and Research Design from the Universidad Autònoma de Barcelona. He is Head of Medical Oncology at the Hospital Clinica Benidorm in Spain, and a member of several national and international medical societies.

He is interested in mathematical modeling of cell growth, differentiation, mutagenesis, carcinogenesis, tumor development, immunology, clonal evolution, drug resistance, pharmacokinetics, and pharmakodynamics. Other interests are painting, mountain biking, and swimming.

Project: A Causal Network of Laboratory Tests

Blood is a body fluid that serves as a carrier of cells and substances. Phlebotomy has been known for more than 2,500 years, but the modern venopuncture and chemical analysis developed in the last 100 years have allowed the detection of those substances in blood, plasma (blood after removing the cells), and serum (plasma after removing clot factors).

Any body substance concentration is the result of a balance between its production and elimination, thus, it is influenced by the action of other substances that alter its production or elimination rate. Interacting substances produce feedback loops that result in stable concentration levels in a normal range, optimal for the physiologic functioning (which is called homeostasis).

Blood determinations follow a normal or a log-normal distribution, and extreme values are considered abnormal. This abnormality may be the result of the technical methodology, fluctuation due to other interacting factors, or pathology.

This project presents the interactions for different blood determinations for which there exists information in medical sources. Information about other substances not commonly analyzed, processes or conditions that may affect this result, and processes or conditions that may be affected by the result will be presented, as well as the interaction network.

Favorite Four-Color, Four State Turing Machine

Rule 14325448312827081304317